| 2. Round | 21/07/2018 | General Díaz | - | Club Olimpia | 1:1 | ||||
| 3. Round | 29/07/2018 | Club Olimpia | - | Deportivo Santaní | 0:1 | ||||
| 4. Round | 05/08/2018 | Sportivo Luqueño | - | Club Olimpia | 0:1 | ||||
| 5. Round | 12/08/2018 | Club Olimpia | - | Deportivo Capiatá | 4:1 | ||||
| 6. Round | 19/08/2018 | Cerro Porteño | - | Club Olimpia | 0:2 |  |
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| 7. Round | 26/08/2018 | Club Olimpia | - | Independiente CG | 3:2 | ||||
| 8. Round | 02/09/2018 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 9. Round | 09/09/2018 | Club Olimpia | - | Libertad | 1:0 | ||||
| 10. Round | 15/09/2018 | Sol de América | - | Club Olimpia | 2:1 | ||||
| 11. Round | 22/09/2018 | Club Olimpia | - | 3 de Febrero | 1:0 | ||||
| 12. Round | 30/09/2018 | Club Olimpia | - | Club Nacional | 2:0 | ||||
| 13. Round | 07/10/2018 | Club Olimpia | - | General Díaz | 2:2 | ||||
| 14. Round | 15/10/2018 | Deportivo Santaní | - | Club Olimpia | 0:5 | |
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| 15. Round | 21/10/2018 | Club Olimpia | - | Sportivo Luqueño | 4:2 | ||||
| 16. Round | 28/10/2018 | Deportivo Capiatá | - | Club Olimpia | 1:4 | ||||
| 17. Round | 04/11/2018 | Club Olimpia | - | Cerro Porteño | 2:2 |
Paraguay