| 3. Round | 28/08/2021 | SV 07 Elversberg [Youth B] | - | Eintracht Frankfurt [Youth B] | 0:4 | ||||
| 4. Round | 12/09/2021 | Eintracht Frankfurt [Youth B] | - | VfB Stuttgart [Youth B] | 0:7 | ||||
| 1. Round | 15/09/2021 | Karlsruher SC [Youth B] | - | Eintracht Frankfurt [Youth B] | 1:1 | ||||
| 5. Round | 19/09/2021 | 1. FSV Mainz 05 [Youth B] | - | Eintracht Frankfurt [Youth B] | 1:1 |  |
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| 6. Round | 26/09/2021 | Eintracht Frankfurt [Youth B] | - | SpVgg Unterhaching [Youth B] | 1:2 | ||||
| 8. Round | 17/10/2021 | Eintracht Frankfurt [Youth B] | - | 1. FC Nürnberg [Youth B] | 0:2 | ||||
| 9. Round | 30/10/2021 | Bayern München [Youth B] | - | Eintracht Frankfurt [Youth B] | 1:0 | ||||
| 10. Round | 06/11/2021 | Eintracht Frankfurt [Youth B] | - | Stuttgarter Kickers [Youth B] | 2:2 | ||||
| 12. Round | 27/11/2021 | Eintracht Frankfurt [Youth B] | - | SpVgg Greuther Fürth [Youth B] | 1:3 | ||||
| 11. Round | 13/02/2022 | FC Augsburg [Youth B] | - | Eintracht Frankfurt [Youth B] | 3:1 | ||||
| 17. Round | 06/03/2022 | Eintracht Frankfurt [Youth B] | - | SV Darmstadt 98 [Youth B] | 0:1 | ||||
| 18. Round | 13/03/2022 | 1. FC Kaiserslautern [Youth B] | - | Eintracht Frankfurt [Youth B] | 2:0 |
Portugal