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| 11/09/2021 | 10:00 | SC Freiburg | - | 1. FSV Mainz 05 | 0:1 (0:0) | |
| 10:00 | FC Ingolstadt 04 | - | FSV Frankfurt | 2:0 (1:0) | ||
| 10:00 | TSV 1860 München | - | 1899 Hoffenheim | 0:1 (0:0) | ||
| 12:00 | FC Augsburg | - | Bayern München | 4:2 (4:1) | ||
| 13:00 | SV Darmstadt 98 | - | SV 07 Elversberg | 3:1 (2:1) | ||
| 13:00 | 1. FC Heidenheim 1846 | - | Karlsruher SC | 1:1 (0:0) | ||
| 12/09/2021 | 10:00 | SpVgg Greuther Fürth | - | 1. FC Nürnberg | 1:0 (1:0) | |
| 12:00 | 1. FC Kaiserslautern | - | SV Wehen Wiesbaden | 4:1 (2:0) | ||
| 12:00 | Eintracht Frankfurt | - | VfB Stuttgart | 0:7 (0:2) | ||
| 13:00 | SSV Reutlingen | - | SpVgg Unterhaching | 1:2 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SpVgg Unterhaching | 4 | 4 | 0 | 0 | 13:4 | 9 | 12 |
| 2 |
|
VfB Stuttgart | 4 | 3 | 1 | 0 | 17:3 | 14 | 10 |
| 3 |
|
1. FSV Mainz 05 | 4 | 3 | 1 | 0 | 12:2 | 10 | 10 |
| 4 |
|
1899 Hoffenheim | 4 | 3 | 0 | 1 | 13:8 | 5 | 9 |
| 5 |
|
SpVgg Greuther Fürth | 4 | 2 | 1 | 1 | 6:5 | 1 | 7 |
| 6 |
|
Eintracht Frankfurt | 4 | 2 | 1 | 1 | 8:8 | 0 | 7 |
| 7 |
|
1. FC Kaiserslautern | 4 | 2 | 0 | 2 | 11:6 | 5 | 6 |
| 8 |
|
SC Freiburg | 4 | 2 | 0 | 2 | 8:4 | 4 | 6 |
| 9 |
|
FSV Frankfurt | 4 | 2 | 0 | 2 | 5:5 | 0 | 6 |
| 10 |
|
FC Augsburg | 4 | 2 | 0 | 2 | 9:10 | -1 | 6 |
| 11 |
|
SV Darmstadt 98 | 4 | 2 | 0 | 2 | 7:9 | -2 | 6 |
| 12 |
|
Karlsruher SC | 4 | 1 | 2 | 1 | 5:4 | 1 | 5 |
| 13 |
|
TSV 1860 München | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 |
| 14 |
|
FC Ingolstadt 04 | 4 | 1 | 1 | 2 | 3:10 | -7 | 4 |
| 15 |
|
Bayern München | 3 | 1 | 0 | 2 | 8:7 | 1 | 3 |
| 16 |
|
1. FC Nürnberg | 4 | 1 | 0 | 3 | 6:7 | -1 | 3 |
| 17 |
|
Stuttgarter Kickers | 3 | 1 | 0 | 2 | 5:10 | -5 | 3 |
| 18 |
|
SV Wehen Wiesbaden | 4 | 1 | 0 | 3 | 4:10 | -6 | 3 |
| 19 |
|
SV 07 Elversberg | 4 | 1 | 0 | 3 | 4:12 | -8 | 3 |
| 20 |
|
1. FC Heidenheim 1846 | 3 | 0 | 2 | 1 | 5:11 | -6 | 2 |
| 21 |
|
SSV Reutlingen | 4 | 0 | 0 | 4 | 2:16 | -14 | 0 |
| Playoffs | |
| Relegation |
