| 2. Round | 31/07/2021 | CF América [U18] | - | Club Necaxa [U18] | 2:3 |  |
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| 3. Round | 06/08/2021 | Club Necaxa [U18] | - | Cruz Azul [U18] | 5:0 | |
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| 4. Round | 12/08/2021 | Atlético San Luis [U18] | - | Club Necaxa [U18] | 3:3 | ||||
| 5. Round | 17/08/2021 | Club Necaxa [U18] | - | Pumas UNAM [U18] | 4:2 | ||||
| 6. Round | 22/08/2021 | Club Necaxa [U18] | - | FC Juárez [U18] | 3:2 | ||||
| 7. Round | 28/08/2021 | Deportivo Guadalajara [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 8. Round | 12/09/2021 | Gallos Blancos [U18] | - | Club Necaxa [U18] | 1:1 | ||||
| 16. Round | 29/10/2021 | Club Necaxa [U18] | - | Mazatlán FC [U18] | 3:0 |
Mexico