| 1. Round | 16/07/2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 |  |
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| 8. Round | 24/08/2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 10. Round | 03/09/2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 13. Round | 24/09/2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 14. Round | 01/10/2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 | ||||
| 17. Round | 18/10/2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 22. Round | 24/11/2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Round | 06/12/2021 | Newell's Old Boys II | - | Banfield II | 2:0 | ||||
| 25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina