| 5. Round | 17/08/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 |  |
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| 9. Round | 18/09/2021 | Deportivo Toluca [U20] | - | CF América [U20] | 3:1 | ||||
| 13. Round | 17/10/2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 4:1 | ||||
| 15. Round | 24/10/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 3:0 | ||||
| 16. Round | 31/10/2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 | ||||
| 17. Round | 05/11/2021 | Puebla FC [U20] | - | Deportivo Toluca [U20] | 0:3 | |
Mexico