| 1. Round | 09/01/2022 | Pumas UNAM [U20] | - | Deportivo Toluca [U20] | 1:1 | ||||
| 2. Round | 16/01/2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 4:2 | ||||
| 3. Round | 21/01/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 |  |
|||
| 8. Round | 01/03/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 3:1 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 1:2 | |
|||
| 12. Round | 03/04/2022 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 2:0 | ||||
| 13. Round | 09/04/2022 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 15. Round | 19/04/2022 | Deportivo Toluca [U20] | - | FC Juárez [U20] | 2:0 | ||||
| 16. Round | 24/04/2022 | Deportivo Toluca [U20] | - | Atlas Guadalajara [U20] | 2:1 | ||||
| 14. Round | 27/04/2022 | UANL Tigres [U20] | - | Deportivo Toluca [U20] | 0:0 | ||||
| 17. Round | 01/05/2022 | Club León [U20] | - | Deportivo Toluca [U20] | 3:1 |
Mexico