| 10. Round | 22/07/2021 | Blooming | - | The Strongest | 2:0 | ||||
| 12. Round | 31/07/2021 | Club Aurora | - | The Strongest | 0:1 |  |
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| 6. Round | 11/08/2021 | Always Ready | - | The Strongest | 2:1 | ||||
| 15. Round | 15/08/2021 | The Strongest | - | Real Santa Cruz | 1:2 |  |
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| 18. Round | 13/09/2021 | The Strongest | - | Independiente Petrolero | 1:1 | ||||
| 19. Round | 19/09/2021 | The Strongest | - | Jorge Wilstermann | 3:1 | ||||
| 20. Round | 22/09/2021 | Atlético Palmaflor | - | The Strongest | 0:0 | ||||
| 21. Round | 27/09/2021 | The Strongest | - | Always Ready | 1:1 | ||||
| 22. Round | 19/10/2021 | Royal Pari | - | The Strongest | 0:1 | |
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| 23. Round | 23/10/2021 | The Strongest | - | Real Potosí | 1:0 | ||||
| 24. Round | 26/10/2021 | CD Guabirá | - | The Strongest | 0:0 | ||||
| 25. Round | 30/10/2021 | The Strongest | - | Blooming | 2:1 | ||||
| 26. Round | 21/11/2021 | Bolívar | - | The Strongest | 0:1 | ||||
| 27. Round | 26/11/2021 | The Strongest | - | Club Aurora | 3:0 | |
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| 29. Round | 05/12/2021 | The Strongest | - | Club San José | 2:0 | |
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| 30. Round | 12/12/2021 | Real Santa Cruz | - | The Strongest | 1:0 |
Paraguay