| 1. Round | 02/08/2009 | Sporting Charleroi | - | Club Brugge KV | 1:2 | ||||
| 2. Round | 09/08/2009 | Club Brugge KV | - | Sporting Lokeren | 2:0 |  |
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| 11. Round | 18/10/2009 | Club Brugge KV | - | KAA Gent | 1:0 | ||||
| 13. Round | 31/10/2009 | Club Brugge KV | - | Sint-Truidense VV | 1:0 | ||||
| 14. Round | 08/11/2009 | Standard Liège | - | Club Brugge KV | 3:1 | ||||
| 15. Round | 21/11/2009 | Club Brugge KV | - | Germinal Beerschot | 1:2 | |
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| 16. Round | 28/11/2009 | Club Brugge KV | - | Sporting Charleroi | 1:0 | ||||
| 17. Round | 06/12/2009 | Sporting Lokeren | - | Club Brugge KV | 0:1 |  |
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| 18. Round | 12/12/2009 | Club Brugge KV | - | KV Mechelen | 1:1 | ||||
| 20. Round | 26/12/2009 | Club Brugge KV | - | Cercle Brugge | 2:1 | |
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| 21. Round | 30/12/2009 | KV Kortrijk | - | Club Brugge KV | 1:4 | ||||
| 23. Round | 24/01/2010 | KRC Genk | - | Club Brugge KV | 2:0 | |
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| 19. Round | 03/02/2010 | RSC Anderlecht | - | Club Brugge KV | 3:2 | ||||
| 25. Round | 07/02/2010 | SV Zulte Waregem | - | Club Brugge KV | 1:1 | ||||
| 27. Round | 21/02/2010 | Club Brugge KV | - | Standard Liège | 2:1 | ||||
| 28. Round | 28/02/2010 | Sint-Truidense VV | - | Club Brugge KV | 1:1 |
Netherlands