| 1. Round | 16/07/2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Round | 27/07/2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 4. Round | 30/07/2021 | Rosario Central II | - | Aldosivi II | 4:1 | ||||
| 5. Round | 06/08/2021 | Sarmiento de Junín II | - | Rosario Central II | 2:2 | ||||
| 8. Round | 24/08/2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 13. Round | 24/09/2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Round | 01/10/2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 19. Round | 29/10/2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 |
Argentina