| 15. Round | 11/10/2021 | San Lorenzo II | - | Colón de Santa Fe II | 1:1 | ||||
| 19. Round | 29/10/2021 | Patronato de Paraná II | - | Colón de Santa Fe II | 0:1 | ||||
| 21. Round | 17/11/2021 | Racing Club II | - | Colón de Santa Fe II | 1:1 | ||||
| 22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Round | 30/11/2021 | Defensa y Justicia II | - | Colón de Santa Fe II | 0:2 | ||||
| 24. Round | 03/12/2021 | Colón de Santa Fe II | - | Atlético Tucumán II | 1:0 | ||||
| 25. Round | 09/12/2021 | Unión de Santa Fe II | - | Colón de Santa Fe II | 0:1 |
Argentina