| 1. Round | 07/02/2021 | Club Olimpia | - | Libertad | 0:1 | ||||
| 3. Round | 15/02/2021 | Libertad | - | Cerro Porteño | 2:1 | ||||
| 9. Round | 22/03/2021 | Libertad | - | Sportivo Luqueño | 2:0 | ||||
| 7. Round | 29/03/2021 | Libertad | - | Guaraní | 1:1 | ||||
| 10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 11. Round | 12/04/2021 | Libertad | - | Guaireña FC | 2:1 | ||||
| 12. Round | 18/04/2021 | Cerro Porteño | - | Libertad | 0:3 |  |
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| 17. Round | 22/05/2021 | Libertad | - | Sol de América | 1:2 | ||||
| 18. Round | 29/05/2021 | Sportivo Luqueño | - | Libertad | 1:3 |  |
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Paraguay