| 2. Round | 17/07/2022 | Carlos Stein | - | Ayacucho FC | 2:2 | ||||
| 3. Round | 22/07/2022 | Ayacucho FC | - | Universidad Cesar Vallejo | 0:1 |  |
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| 4. Round | 27/07/2022 | Universidad San Martín | - | Ayacucho FC | 3:3 | ||||
| 5. Round | 30/07/2022 | Ayacucho FC | - | Cienciano | 0:1 | ||||
| 6. Round | 06/08/2022 | Deportivo Binacional | - | Ayacucho FC | 4:1 | ||||
| 7. Round | 13/08/2022 | Ayacucho FC | - | AD Tarma | 1:2 | |
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| 8. Round | 19/08/2022 | Universidad Técnica | - | Ayacucho FC | 2:1 | ||||
| 9. Round | 28/08/2022 | Universitario de Deportes | - | Ayacucho FC | 2:1 | ||||
| 10. Round | 02/09/2022 | Ayacucho FC | - | Sport Boys | 1:1 |  |
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| 11. Round | 11/09/2022 | Atlético Grau | - | Ayacucho FC | 3:0 | ||||
| 12. Round | 19/09/2022 | Ayacucho FC | - | Alianza Atlético | 2:0 | |
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| 13. Round | 01/10/2022 | Mannucci | - | Ayacucho FC | 0:1 | ||||
| 14. Round | 05/10/2022 | Ayacucho FC | - | Sporting Cristal | 0:1 | ||||
| 18. Round | 25/10/2022 | Ayacucho FC | - | Alianza Lima | 0:1 | ||||
| 19. Round | 29/10/2022 | Academia Cantolao | - | Ayacucho FC | 1:1 | |
Uruguay