| 2. Round | 15/01/2022 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 1. Round | 19/01/2022 | Club León [U20] | - | Atlas Guadalajara [U20] | 1:1 |  |
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| 5. Round | 11/02/2022 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 1:2 | ||||
| 6. Round | 20/02/2022 | Atlas Guadalajara [U20] | - | Pumas UNAM [U20] | 0:0 | ||||
| 7. Round | 25/02/2022 | Club Tijuana [U20] | - | Atlas Guadalajara [U20] | 2:1 | ||||
| 8. Round | 02/03/2022 | Atlas Guadalajara [U20] | - | CF Pachuca [U20] | 0:3 | ||||
| 9. Round | 05/03/2022 | Gallos Blancos [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 10. Round | 11/03/2022 | FC Juárez [U20] | - | Atlas Guadalajara [U20] | 0:0 | ||||
| 11. Round | 20/03/2022 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 1:2 | ||||
| 12. Round | 02/04/2022 | Cruz Azul [U20] | - | Atlas Guadalajara [U20] | 1:0 | ||||
| 13. Round | 07/04/2022 | Atlas Guadalajara [U20] | - | Club Necaxa [U20] | 1:1 | |
USA
Mexico