| 19. Round | 01/08/2021 | San Telmo | - | Independiente Rivadavia | 1:0 | ||||
| 20. Round | 06/08/2021 | Atlético Rafaela | - | San Telmo | 2:2 | ||||
| 21. Round | 15/08/2021 | San Telmo | - | Guillermo Brown | 1:2 | ||||
| 22. Round | 21/08/2021 | Brown de Adrogué | - | San Telmo | 2:2 | ||||
| 23. Round | 28/08/2021 | San Telmo | - | San Martín de San Juan | 2:1 | ||||
| 24. Round | 04/09/2021 | Villa Dálmine | - | San Telmo | 3:3 |  |
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| 25. Round | 13/09/2021 | All Boys | - | San Telmo | 3:0 | ||||
| 26. Round | 19/09/2021 | San Telmo | - | Defensores de Belgrano | 0:0 |  |
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| 28. Round | 01/10/2021 | San Telmo | - | Almagro | 2:1 | ||||
| 31. Round | 27/10/2021 | Ferro Carril Oeste | - | San Telmo | 6:0 |
Argentina