| 3. Round | 16/06/2022 | Argentinos Juniors | - | Independiente | 2:1 | ||||
| 4. Round | 21/06/2022 | Independiente | - | Estudiantes | 2:1 | ||||
| 5. Round | 27/06/2022 | Patronato de Paraná | - | Independiente | 3:1 | ||||
| 6. Round | 05/07/2022 | Independiente | - | Platense | 1:3 | ||||
| 7. Round | 10/07/2022 | Racing Club | - | Independiente | 1:0 | ||||
| 8. Round | 16/07/2022 | Independiente | - | Rosario Central | 0:0 | ||||
| 9. Round | 20/07/2022 | Defensa y Justicia | - | Independiente | 2:1 | ||||
| 10. Round | 24/07/2022 | Independiente | - | Atlético Tucumán | 0:1 | ||||
| 16. Round | 28/08/2022 | Independiente | - | Vélez Sarsfield | 1:1 | ||||
| 17. Round | 04/09/2022 | Gimnasia de La Plata | - | Independiente | 3:1 |
Uruguay