| 2. Round | 20/08/2021 | Kayserispor | - | Adana Demirspor | 1:1 |  |
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| 3. Round | 27/08/2021 | Adana Demirspor | - | Konyaspor | 1:1 | ||||
| 4. Round | 11/09/2021 | Fatih Karagümrük | - | Adana Demirspor | 4:0 | ||||
| 12. Round | 07/11/2021 | Adana Demirspor | - | Hatayspor | 1:0 | |
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| 13. Round | 21/11/2021 | Altay Izmir | - | Adana Demirspor | 1:3 | ||||
| 19. Round | 26/12/2021 | Göztepe | - | Adana Demirspor | 1:1 | ||||
| 21. Round | 15/01/2022 | Adana Demirspor | - | Kayserispor | 1:1 | ||||
| 23. Round | 22/01/2022 | Adana Demirspor | - | Fatih Karagümrük | 5:0 | ||||
| 24. Round | 06/02/2022 | Çaykur Rizespor | - | Adana Demirspor | 1:3 | ||||
| 36. Round | 07/05/2022 | Adana Demirspor | - | Alanyaspor | 1:2 | |
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| 37. Round | 16/05/2022 | Galatasaray | - | Adana Demirspor | 3:2 | ||||
| 38. Round | 22/05/2022 | Adana Demirspor | - | Göztepe | 7:0 |
Germany