| 3. Round | 13/08/2021 | CF Monterrey II | - | Tapatío | 2:0 | ||||
| 4. Round | 18/08/2021 | Venados FC | - | CF Monterrey II | 1:1 | ||||
| 5. Round | 26/08/2021 | CF Monterrey II | - | Club Celaya | 1:0 | ||||
| 6. Round | 01/09/2021 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:0 | ||||
| 8. Round | 16/09/2021 | Cimarrones de Sonora | - | CF Monterrey II | 1:2 | ||||
| 9. Round | 21/09/2021 | CF Monterrey II | - | Mineros de Zacatecas | 0:1 |  |
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| 10. Round | 28/09/2021 | Tepatitlán | - | CF Monterrey II | 1:1 | ||||
| 11. Round | 06/10/2021 | CF Monterrey II | - | Coyotes de Tlaxcala | 4:1 | ||||
| 13. Round | 19/10/2021 | CF Monterrey II | - | Leones Negros | 0:1 | ||||
| 15. Round | 07/11/2021 | CF Monterrey II | - | Pumas Tabasco | 1:1 | ||||
| 16. Round | 11/11/2021 | Correcaminos UAT | - | CF Monterrey II | 2:1 | ||||
| 17. Round | 16/11/2021 | CF Monterrey II | - | Atlético Morelia | 0:1 |
Mexico