| 3. Round | 26/09/2020 | Fleetwood Town | - | AFC Wimbledon | 0:1 |  |
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| 4. Round | 03/10/2020 | AFC Wimbledon | - | Accrington Stanley | 1:2 | ||||
| 5. Round | 10/10/2020 | Swindon Town | - | AFC Wimbledon | 0:1 | ||||
| 6. Round | 17/10/2020 | AFC Wimbledon | - | Shrewsbury Town | 0:1 | ||||
| 7. Round | 20/10/2020 | Hull City | - | AFC Wimbledon | 1:0 | ||||
| 8. Round | 24/10/2020 | Burton Albion | - | AFC Wimbledon | 1:1 | ||||
| 9. Round | 27/10/2020 | AFC Wimbledon | - | Blackpool FC | 1:0 | ||||
| 10. Round | 31/10/2020 | Milton Keynes Dons | - | AFC Wimbledon | 1:1 | ||||
| 11. Round | 03/11/2020 | AFC Wimbledon | - | Doncaster Rovers | 2:2 | ||||
| 13. Round | 21/11/2020 | Rochdale AFC | - | AFC Wimbledon | 0:1 | ||||
| 14. Round | 24/11/2020 | Gillingham FC | - | AFC Wimbledon | 2:1 | ||||
| 16. Round | 05/12/2020 | AFC Wimbledon | - | Bristol Rovers | 2:4 | ||||
| 17. Round | 12/12/2020 | Charlton Athletic | - | AFC Wimbledon | 5:2 | ||||
| 18. Round | 15/12/2020 | Sunderland AFC | - | AFC Wimbledon | 1:1 | ||||
| 19. Round | 19/12/2020 | AFC Wimbledon | - | Crewe Alexandra | 1:2 | ||||
| 20. Round | 26/12/2020 | Oxford United | - | AFC Wimbledon | 2:0 |
England