| 1. Round | 30/07/2022 | Derby County | - | Oxford United | 1:0 |  |
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| 2. Round | 06/08/2022 | Oxford United | - | Cambridge United | 1:0 | ||||
| 3. Round | 13/08/2022 | Bristol Rovers | - | Oxford United | 1:0 | |
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| 4. Round | 16/08/2022 | Oxford United | - | Lincoln City | 1:2 | |
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| 5. Round | 20/08/2022 | Oxford United | - | Morecambe FC | 1:1 | ||||
| 6. Round | 27/08/2022 | Cheltenham Town | - | Oxford United | 1:2 | ||||
| 9. Round | 13/09/2022 | Plymouth Argyle | - | Oxford United | 1:0 | ||||
| 13. Round | 25/10/2022 | Portsmouth FC | - | Oxford United | 1:1 | ||||
| 17. Round | 29/10/2022 | Bolton Wanderers | - | Oxford United | 1:3 |  |
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| 11. Round | 01/11/2022 | Oxford United | - | Fleetwood Town | 1:1 | |
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| 18. Round | 12/11/2022 | Oxford United | - | Port Vale FC | 4:0 | ||||
| 19. Round | 19/11/2022 | Oxford United | - | Forest Green Rovers | 1:1 | ||||
| 24. Round | 29/12/2022 | Oxford United | - | Charlton Athletic | 3:1 |
England