| 1. Round | 24/07/2021 | Hansa Rostock | - | Karlsruher SC | 1:3 | ||||
| 2. Round | 31/07/2021 | Hannover 96 | - | Hansa Rostock | 0:3 | ||||
| 3. Round | 15/08/2021 | 1. FC Heidenheim 1846 | - | Hansa Rostock | 1:1 |  |
|||
| 4. Round | 21/08/2021 | Hansa Rostock | - | Dynamo Dresden | 1:3 |  |
|||
| 5. Round | 29/08/2021 | Werder Bremen | - | Hansa Rostock | 3:0 | ||||
| 6. Round | 12/09/2021 | Hansa Rostock | - | SV Darmstadt 98 | 2:1 | ||||
| 7. Round | 17/09/2021 | 1. FC Nürnberg | - | Hansa Rostock | 1:0 | ||||
| 10. Round | 17/10/2021 | Hansa Rostock | - | SV Sandhausen | 1:1 | ||||
| 11. Round | 24/10/2021 | FC St. Pauli | - | Hansa Rostock | 4:0 | ||||
| 12. Round | 31/10/2021 | Hansa Rostock | - | Fortuna Düsseldorf | 2:1 | ||||
| 13. Round | 06/11/2021 | Jahn Regensburg | - | Hansa Rostock | 2:3 | ||||
| 14. Round | 20/11/2021 | Hansa Rostock | - | Erzgebirge Aue | 1:2 | ||||
| 15. Round | 28/11/2021 | SC Paderborn 07 | - | Hansa Rostock | 1:1 | ||||
| 17. Round | 12/12/2021 | Hamburger SV | - | Hansa Rostock | 3:0 | ||||
| 18. Round | 19/12/2021 | Karlsruher SC | - | Hansa Rostock | 2:2 |
Germany
Congo DR 