| 1. Round | 24/07/2021 | Shakhtar Donetsk | - | Inhulets Petrove | 2:1 | ||||
| 2. Round | 30/07/2021 | FK Lviv | - | Shakhtar Donetsk | 0:3 | ||||
| 3. Round | 07/08/2021 | Shakhtar Donetsk | - | FK Oleksandriya | 1:2 | ||||
| 4. Round | 13/08/2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 |  |
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| 5. Round | 21/08/2021 | Chernomorets Odessa | - | Shakhtar Donetsk | 0:3 | ||||
| 6. Round | 29/08/2021 | FC Mynai | - | Shakhtar Donetsk | 1:1 | ||||
| 7. Round | 11/09/2021 | Shakhtar Donetsk | - | SK Dnipro-1 | 2:0 | ||||
| 8. Round | 18/09/2021 | FK Mariupol | - | Shakhtar Donetsk | 0:5 | ||||
| 10. Round | 03/10/2021 | Dinamo Kiev | - | Shakhtar Donetsk | 0:0 | ||||
| 12. Round | 23/10/2021 | Vorskla Poltava | - | Shakhtar Donetsk | 0:2 | ||||
| 13. Round | 30/10/2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:1 |  |
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| 17. Round | 03/12/2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 | |
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| 18. Round | 11/12/2021 | FK Oleksandriya | - | Shakhtar Donetsk | 1:2 |
Ukraine