| 14. Round | 01/03/1981 | Servette FC | - | AC Bellinzona | 0:1 | ||||
| 15. Round | 08/03/1981 | AC Bellinzona | - | FC Luzern | 0:0 | ||||
| 16. Round | 14/03/1981 | Grasshopper Club Zürich | - | AC Bellinzona | 3:0 | ||||
| 17. Round | 22/03/1981 | FC Nordstern Basel | - | AC Bellinzona | 1:2 | ||||
| 18. Round | 05/04/1981 | AC Bellinzona | - | Lausanne Sports | 1:2 | ||||
| 19. Round | 11/04/1981 | BSC Young Boys | - | AC Bellinzona | 2:0 | ||||
| 20. Round | 25/04/1981 | AC Bellinzona | - | CS Chênois | 3:1 | ||||
| 21. Round | 02/05/1981 | FC Zürich | - | AC Bellinzona | 3:1 | ||||
| 22. Round | 09/05/1981 | AC Bellinzona | - | FC St. Gallen | 2:0 | ||||
| 23. Round | 16/05/1981 | FC Chiasso | - | AC Bellinzona | 5:1 | ||||
| 24. Round | 23/05/1981 | AC Bellinzona | - | FC Basel 1893 | 1:1 | ||||
| 25. Round | 04/06/1981 | AC Bellinzona | - | Neuchâtel Xamax FC | 1:0 | ||||
| 26. Round | 13/06/1981 | FC Sion | - | AC Bellinzona | 3:1 |
Switzerland