| 3. Round | 27/08/2021 | Adana Demirspor | - | Konyaspor | 1:1 | ||||
| 5. Round | 18/09/2021 | Adana Demirspor | - | Çaykur Rizespor | 3:1 | ||||
| 6. Round | 21/09/2021 | Beşiktaş | - | Adana Demirspor | 3:3 | ||||
| 7. Round | 25/09/2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 9. Round | 16/10/2021 | Adana Demirspor | - | Yeni Malatyaspor | 0:2 | ||||
| 10. Round | 24/10/2021 | Sivasspor | - | Adana Demirspor | 1:1 | ||||
| 12. Round | 07/11/2021 | Adana Demirspor | - | Hatayspor | 1:0 | ||||
| 15. Round | 04/12/2021 | Trabzonspor | - | Adana Demirspor | 2:0 | ||||
| 16. Round | 12/12/2021 | Adana Demirspor | - | Giresunspor | 1:0 | ||||
| 19. Round | 26/12/2021 | Göztepe | - | Adana Demirspor | 1:1 | ||||
| 20. Round | 10/01/2022 | Fenerbahçe | - | Adana Demirspor | 1:2 | ||||
| 21. Round | 15/01/2022 | Adana Demirspor | - | Kayserispor | 1:1 |
Germany