| 1. Round | 16/08/2021 | Sunderland AFC U23 | - | Fulham FC U23 | 3:4 |  |
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| 2. Round | 20/08/2021 | Fulham FC U23 | - | West Bromwich Albion U23 | 3:0 | |
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| 3. Round | 27/08/2021 | Aston Villa U23 | - | Fulham FC U23 | 1:1 | ||||
| 5. Round | 20/09/2021 | Wolverhampton Wanderers U23 | - | Fulham FC U23 | 2:1 | ||||
| 6. Round | 24/09/2021 | Fulham FC U23 | - | Newcastle United U23 | 3:1 | |
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| 7. Round | 01/10/2021 | Norwich City U23 | - | Fulham FC U23 | 0:2 | ||||
| 8. Round | 15/10/2021 | Fulham FC U23 | - | Reading FC U23 | 3:0 | |
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| 9. Round | 22/10/2021 | Fulham FC U23 | - | Nottingham Forest U23 | 2:1 | ||||
| 10. Round | 01/11/2021 | Fulham FC U23 | - | Middlesbrough FC U23 | 2:0 | |
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| 12. Round | 19/11/2021 | Fulham FC U23 | - | Stoke City U23 | 3:0 | |
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| 14. Round | 03/12/2021 | Fulham FC U23 | - | Wolverhampton Wanderers U23 | 4:2 | ||||
| 25. Round | 25/04/2022 | Reading FC U23 | - | Fulham FC U23 | 3:1 |
Ghana