| Group D | 17/09/2015 | FC Midtjylland | - | Legia Warszawa | 1:0 | ||||
| Group D | 01/10/2015 | Club Brugge KV | - | FC Midtjylland | 1:3 | ||||
| Group D | 22/10/2015 | FC Midtjylland | - | SSC Napoli | 1:4 | ||||
| Group D | 05/11/2015 | SSC Napoli | - | FC Midtjylland | 5:0 | ||||
| Group D | 26/11/2015 | Legia Warszawa | - | FC Midtjylland | 1:0 |  |
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| Group D | 10/12/2015 | FC Midtjylland | - | Club Brugge KV | 1:1 | ||||
| Round of 32 | 18/02/2016 | FC Midtjylland | - | Manchester United | 2:1 | ||||
| Round of 32 | 25/02/2016 | Manchester United | - | FC Midtjylland | 5:1 |
Finland