| 2. Round | 21/08/2021 | Alanyaspor | - | Altay Izmir | 1:4 | ||||
| 13. Round | 21/11/2021 | Altay Izmir | - | Adana Demirspor | 1:3 | ||||
| 16. Round | 10/12/2021 | Altay Izmir | - | Hatayspor | 1:2 |  |
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| 22. Round | 19/01/2022 | Fenerbahçe | - | Altay Izmir | 2:1 | ||||
| 23. Round | 23/01/2022 | Altay Izmir | - | Konyaspor | 0:1 | ||||
| 24. Round | 06/02/2022 | Göztepe | - | Altay Izmir | 0:2 | ||||
| 25. Round | 11/02/2022 | Altay Izmir | - | Çaykur Rizespor | 0:0 | ||||
| 27. Round | 27/02/2022 | Altay Izmir | - | Gaziantep FK | 3:2 | ||||
| 28. Round | 06/03/2022 | Fatih Karagümrük | - | Altay Izmir | 0:0 | ||||
| 33. Round | 16/04/2022 | Altay Izmir | - | İstanbul Başakşehir | 1:1 | ||||
| 34. Round | 24/04/2022 | Altay Izmir | - | Galatasaray | 0:1 | ||||
| 35. Round | 30/04/2022 | Hatayspor | - | Altay Izmir | 0:1 |
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