| 1. Round | 12/02/2021 | Defensa y Justicia II | - | Huracán II | 3:3 | ||||
| 3. Round | 26/02/2021 | Defensa y Justicia II | - | Patronato de Paraná II | 0:0 | ||||
| 4. Round | 05/03/2021 | Gimnasia de La Plata II | - | Defensa y Justicia II | 3:0 | ||||
| 7. Round | 29/03/2021 | Defensa y Justicia II | - | Vélez Sarsfield II | 1:1 | ||||
| 8. Round | 02/04/2021 | Boca Juniors II | - | Defensa y Justicia II | 1:0 | ||||
| 9. Round | 09/04/2021 | Defensa y Justicia II | - | Talleres de Córdoba II | 5:1 | ||||
| 13. Round | 07/05/2021 | Atlético Tucumán II | - | Defensa y Justicia II | 3:4 |
Argentina