| 1. Round | 16/07/2021 | Huracán II | - | Defensa y Justicia II | 3:0 | ||||
| 14. Round | 01/10/2021 | Defensa y Justicia II | - | Talleres de Córdoba II | 2:2 | ||||
| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 13/10/2021 | Defensa y Justicia II | - | Estudiantes II | 1:2 | ||||
| 17. Round | 18/10/2021 | Patronato de Paraná II | - | Defensa y Justicia II | 2:2 | ||||
| 18. Round | 22/10/2021 | Defensa y Justicia II | - | Platense II | 1:0 | ||||
| 19. Round | 28/10/2021 | Racing Club II | - | Defensa y Justicia II | 2:2 | ||||
| 21. Round | 17/11/2021 | Unión de Santa Fe II | - | Defensa y Justicia II | 1:1 | ||||
| 22. Round | 24/11/2021 | Atlético Tucumán II | - | Defensa y Justicia II | 4:1 | ||||
| 24. Round | 03/12/2021 | River Plate II | - | Defensa y Justicia II | 2:1 | ||||
| 25. Round | 09/12/2021 | Defensa y Justicia II | - | Lanús II | 2:0 |  |
Argentina