| 1. Round | 06/06/2022 | Defensa y Justicia | - | River Plate | 0:0 | ||||
| 2. Round | 12/06/2022 | River Plate | - | Atlético Tucumán | 0:0 | ||||
| 3. Round | 15/06/2022 | Colón de Santa Fe | - | River Plate | 1:0 | ||||
| 6. Round | 04/07/2022 | Huracán | - | River Plate | 3:2 |  |
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| 8. Round | 18/07/2022 | Vélez Sarsfield | - | River Plate | 2:2 | ||||
| 19. Round | 14/09/2022 | River Plate | - | Banfield | 1:2 | ||||
| 20. Round | 18/09/2022 | San Lorenzo | - | River Plate | 0:1 | ||||
| 23. Round | 06/10/2022 | River Plate | - | Estudiantes | 5:0 | ||||
| 26. Round | 17/10/2022 | River Plate | - | Rosario Central | 1:2 | ||||
| 27. Round | 23/10/2022 | Racing Club | - | River Plate | 1:2 |
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