| 1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
| 2. Round | 11/02/2022 | Sportivo Ameliano | - | Resistencia SC | 1:4 | ||||
| 3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
| 4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
| 5. Round | 05/03/2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
| 7. Round | 19/03/2022 | Resistencia SC | - | Cerro Porteño | 0:3 | ||||
| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Round | 08/04/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:1 | ||||
| 12. Round | 25/04/2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
| 16. Round | 14/05/2022 | Guaireña FC | - | Resistencia SC | 0:0 | ||||
| 21. Round | 25/06/2022 | General Caballero DJLM | - | Resistencia SC | 2:1 |
Paraguay