| 1. Round | 16/09/2004 | Shelbourne FC | - | Lille OSC | 2:2 | ||||
| 1. Round | 30/09/2004 | Lille OSC | - | Shelbourne FC | 2:0 | ||||
| Group H | 21/10/2004 | Alemannia Aachen | - | Lille OSC | 1:0 | ||||
| Group H | 04/11/2004 | Lille OSC | - | Zenit St. Petersburg | 2:1 | ||||
| Group H | 25/11/2004 | AEK Athen | - | Lille OSC | 1:2 | ||||
| Group H | 15/12/2004 | Lille OSC | - | Sevilla FC | 1:0 | ||||
| 3. Round | 17/02/2005 | FC Basel 1893 | - | Lille OSC | 0:0 | ||||
| 3. Round | 24/02/2005 | Lille OSC | - | FC Basel 1893 | 2:0 | ||||
| Round of 16 | 10/03/2005 | Lille OSC | - | AJ Auxerre | 0:1 | ||||
| Round of 16 | 17/03/2005 | AJ Auxerre | - | Lille OSC | 0:0 |
Senegal