| 1. Round | 15/08/2010 | Karabükspor | - | Manisaspor | 2:1 |  |
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| 2. Round | 20/08/2010 | Kayserispor | - | Karabükspor | 1:0 | |
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| 3. Round | 29/08/2010 | Karabükspor | - | Beşiktaş | 1:4 | |
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| 4. Round | 13/09/2010 | Kasımpaşa SK | - | Karabükspor | 1:2 | |
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| 6. Round | 26/09/2010 | Konyaspor | - | Karabükspor | 2:2 | ||||
| 7. Round | 01/10/2010 | Karabükspor | - | Galatasaray | 2:1 | ||||
| 8. Round | 15/10/2010 | Bursaspor | - | Karabükspor | 2:2 | ||||
| 9. Round | 22/10/2010 | Karabükspor | - | Eskişehirspor | 1:2 | ||||
| 10. Round | 30/10/2010 | Gaziantepspor | - | Karabükspor | 0:0 | |
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| 11. Round | 06/11/2010 | Karabükspor | - | Bucaspor | 3:0 | ||||
| 12. Round | 14/11/2010 | İstanbul BBSK | - | Karabükspor | 2:1 | ||||
| 14. Round | 28/11/2010 | Karabükspor | - | MKE Ankaragücü | 5:1 | |
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| 15. Round | 05/12/2010 | Fenerbahçe | - | Karabükspor | 2:1 | ||||
| 16. Round | 11/12/2010 | Karabükspor | - | Antalyaspor | 2:0 | |
Brazil