| 22. Round | 26/02/2022 | Neckarsulmer Sport-Union | - | 1. FC Bruchsal | 2:2 |  |
|||
| 23. Round | 05/03/2022 | FSV 08 Bietigheim-Bissingen | - | Neckarsulmer Sport-Union | 0:3 | ||||
| 21. Round | 09/03/2022 | TSV Ilshofen | - | Neckarsulmer Sport-Union | 3:0 | ||||
| 26. Round | 26/03/2022 | Neckarsulmer Sport-Union | - | FC Nöttingen | 0:1 | ||||
| 25. Round | 06/04/2022 | FV Lörrach-Brombach | - | Neckarsulmer Sport-Union | 0:2 | ||||
| 31. Round | 23/04/2022 | SSV Reutlingen | - | Neckarsulmer Sport-Union | 0:2 | ||||
| 32. Round | 27/04/2022 | Neckarsulmer Sport-Union | - | TSG Backnang | 4:1 | ||||
| 33. Round | 30/04/2022 | FV Ravensburg | - | Neckarsulmer Sport-Union | 0:1 | ||||
| 27. Round | 04/05/2022 | SV Oberachern | - | Neckarsulmer Sport-Union | 1:0 | ||||
| 34. Round | 07/05/2022 | Neckarsulmer Sport-Union | - | FC 08 Villingen | 1:2 | ||||
| 35. Round | 14/05/2022 | SV Linx | - | Neckarsulmer Sport-Union | 1:2 | ||||
| 37. Round | 28/05/2022 | Neckarsulmer Sport-Union | - | Sportfreunde Dorfmerkingen | 0:2 | ||||
| 38. Round | 04/06/2022 | 1. CfR Pforzheim | - | Neckarsulmer Sport-Union | 4:0 |
Germany