| 7. Round | 02/10/2021 | FSV Frankfurt [Youth B] | - | Eintracht Frankfurt [Youth B] | 1:2 | ||||
| 8. Round | 10/10/2021 | SV Darmstadt 98 [Youth B] | - | FSV Frankfurt [Youth B] | 0:2 |  |
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| 3. Round | 24/10/2021 | FSV Frankfurt [Youth B] | - | SpVgg Greuther Fürth [Youth B] | 1:2 | ||||
| 9. Round | 31/10/2021 | FSV Frankfurt [Youth B] | - | 1. FC Kaiserslautern [Youth B] | 0:0 | ||||
| 10. Round | 06/11/2021 | 1. FC Heidenheim 1846 [Youth B] | - | FSV Frankfurt [Youth B] | 3:1 | ||||
| 11. Round | 13/11/2021 | FSV Frankfurt [Youth B] | - | TSV 1860 München [Youth B] | 2:1 | |
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| 12. Round | 27/11/2021 | 1899 Hoffenheim [Youth B] | - | FSV Frankfurt [Youth B] | 1:0 | ||||
| 13. Round | 05/12/2021 | FSV Frankfurt [Youth B] | - | Karlsruher SC [Youth B] | 3:2 | ||||
| 14. Round | 11/12/2021 | SV Wehen Wiesbaden [Youth B] | - | FSV Frankfurt [Youth B] | 2:1 | ||||
| 16. Round | 27/02/2022 | VfB Stuttgart [Youth B] | - | FSV Frankfurt [Youth B] | 3:0 | ||||
| 21. Round | 23/04/2022 | Bayern München [Youth B] | - | FSV Frankfurt [Youth B] | 3:2 |
Germany