| 1. Round | 30/07/2016 | Royal Excel Mouscron | - | RSC Anderlecht | 1:2 | ||||
| 2. Round | 06/08/2016 | Royal Excel Mouscron | - | Sporting Charleroi | 0:1 |  |
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| 4. Round | 20/08/2016 | Royal Excel Mouscron | - | Sint-Truidense VV | 2:1 | |
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| 5. Round | 27/08/2016 | Sporting Lokeren | - | Royal Excel Mouscron | 2:1 | ||||
| 6. Round | 10/09/2016 | Royal Excel Mouscron | - | SV Zulte Waregem | 1:5 | ||||
| 7. Round | 17/09/2016 | KVC Westerlo | - | Royal Excel Mouscron | 1:3 | ||||
| 8. Round | 23/09/2016 | Royal Excel Mouscron | - | Club Brugge KV | 0:3 | ||||
| 10. Round | 15/10/2016 | Royal Excel Mouscron | - | KRC Genk | 2:2 |  |
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| 11. Round | 22/10/2016 | KV Mechelen | - | Royal Excel Mouscron | 2:0 | ||||
| 16. Round | 27/11/2016 | RSC Anderlecht | - | Royal Excel Mouscron | 7:0 | ||||
| 17. Round | 03/12/2016 | Sint-Truidense VV | - | Royal Excel Mouscron | 1:0 | |
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| 18. Round | 10/12/2016 | Royal Excel Mouscron | - | KV Mechelen | 1:4 | ||||
| 19. Round | 17/12/2016 | Sporting Charleroi | - | Royal Excel Mouscron | 2:0 | |
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| 20. Round | 20/12/2016 | Royal Excel Mouscron | - | KVC Westerlo | 0:0 |
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