| 1. Round | 30/06/2022 | CF Monterrey II | - | Atlético Morelia | 1:0 |  |
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| 2. Round | 06/07/2022 | Cancún FC | - | CF Monterrey II | 0:1 | ||||
| 3. Round | 13/07/2022 | Tepatitlán | - | CF Monterrey II | 1:2 | ||||
| 4. Round | 21/07/2022 | CF Monterrey II | - | Atlante | 0:0 | ||||
| 5. Round | 27/07/2022 | Coyotes de Tlaxcala | - | CF Monterrey II | 1:1 | ||||
| 6. Round | 04/08/2022 | CF Monterrey II | - | Cimarrones de Sonora | 1:1 | ||||
| 7. Round | 11/08/2022 | Tapatío | - | CF Monterrey II | 1:1 | ||||
| 9. Round | 24/08/2022 | Atlético La Paz | - | CF Monterrey II | 1:0 | ||||
| 10. Round | 02/09/2022 | CF Monterrey II | - | Club Celaya | 2:3 | ||||
| 11. Round | 08/09/2022 | Dorados de Sinaloa | - | CF Monterrey II | 2:1 | |
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| 12. Round | 14/09/2022 | Alacranes de Durango | - | CF Monterrey II | 3:1 | ||||
| 13. Round | 21/09/2022 | CF Monterrey II | - | Leones Negros | 0:1 | ||||
| 14. Round | 24/09/2022 | Correcaminos UAT | - | CF Monterrey II | 1:1 | ||||
| 15. Round | 27/09/2022 | CF Monterrey II | - | Mineros de Zacatecas | 0:3 | |
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| 16. Round | 06/10/2022 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:1 | ||||
| 17. Round | 11/10/2022 | CF Monterrey II | - | Pumas Tabasco | 2:2 |
Mexico