| 5. Round | 06/08/2021 | Aldosivi II | - | Defensa y Justicia II | 1:2 | ||||
| 6. Round | 13/08/2021 | Defensa y Justicia II | - | Sarmiento de Junín II | 3:0 | ||||
| 7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
| 9. Round | 27/08/2021 | Arsenal de Sarandí II | - | Defensa y Justicia II | 0:1 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia II | - | Central Córdoba SdE II | 0:1 | ||||
| 11. Round | 09/09/2021 | Boca Juniors II | - | Defensa y Justicia II | 3:2 | ||||
| 13. Round | 24/09/2021 | San Lorenzo II | - | Defensa y Justicia II | 0:2 | ||||
| 14. Round | 01/10/2021 | Defensa y Justicia II | - | Talleres de Córdoba II | 2:2 | ||||
| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 13/10/2021 | Defensa y Justicia II | - | Estudiantes II | 1:2 | ||||
| 17. Round | 18/10/2021 | Patronato de Paraná II | - | Defensa y Justicia II | 2:2 | ||||
| 18. Round | 22/10/2021 | Defensa y Justicia II | - | Platense II | 1:0 | ||||
| 19. Round | 28/10/2021 | Racing Club II | - | Defensa y Justicia II | 2:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 |
Argentina