| 1. Round | 27/07/2000 | San Lorenzo | - | Gimnasia de La Plata | 3:0 | ||||
| 3. Round | 19/08/2000 | San Lorenzo | - | Racing Club | 3:1 | ||||
| 4. Round | 26/08/2000 | Belgrano de Córdoba | - | San Lorenzo | 0:1 |  |
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| 5. Round | 04/09/2000 | San Lorenzo | - | Almagro | 2:0 | ||||
| 6. Round | 09/09/2000 | Huracán | - | San Lorenzo | 2:1 | ||||
| 7. Round | 16/09/2000 | San Lorenzo | - | Lanús | 4:2 | ||||
| 8. Round | 23/09/2000 | River Plate | - | San Lorenzo | 2:2 | ||||
| 9. Round | 30/09/2000 | San Lorenzo | - | Vélez Sarsfield | 0:1 | ||||
| 10. Round | 13/10/2000 | Colón de Santa Fe | - | San Lorenzo | 3:2 | ||||
| 11. Round | 21/10/2000 | San Lorenzo | - | Rosario Central | 4:1 | ||||
| 12. Round | 28/10/2000 | Independiente | - | San Lorenzo | 1:2 | ||||
| 13. Round | 02/11/2000 | San Lorenzo | - | Talleres de Córdoba | 1:1 | ||||
| 14. Round | 09/11/2000 | CA Los Andes | - | San Lorenzo | 0:1 | ||||
| 15. Round | 18/11/2000 | San Lorenzo | - | Estudiantes | 1:1 | ||||
| 16. Round | 25/11/2000 | San Lorenzo | - | Chacarita Juniors | 4:0 | ||||
| 17. Round | 02/12/2000 | Boca Juniors | - | San Lorenzo | 1:0 | ||||
| 18. Round | 09/12/2000 | San Lorenzo | - | Argentinos Juniors | 2:1 |  |
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| 19. Round | 14/12/2000 | Unión de Santa Fe | - | San Lorenzo | 0:0 |
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