| 3. Round | 04/09/2021 | Stade Rennais [Youth] | - | FC Nantes [Youth] | 0:3 | ||||
| 4. Round | 12/09/2021 | Angers SCO [Youth] | - | Stade Rennais [Youth] | 3:0 | ||||
| 5. Round | 18/09/2021 | Stade Rennais [Youth] | - | LB Châteauroux [Youth] | 3:2 | ||||
| 6. Round | 26/09/2021 | US Avranches [Youth] | - | Stade Rennais [Youth] | 2:3 | ||||
| 7. Round | 02/10/2021 | Stade Rennais [Youth] | - | US Concarneau [Youth] | 2:1 |  |
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| 8. Round | 10/10/2021 | Stade Lavallois [Youth] | - | Stade Rennais [Youth] | 2:1 | ||||
| 9. Round | 16/10/2021 | Stade Rennais [Youth] | - | Tours FC [Youth] | 5:1 | |
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| 10. Round | 23/10/2021 | Stade Rennais [Youth] | - | Stade Brestois 29 [Youth] | 3:1 | |
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| 13. Round | 27/11/2021 | SA Mérignac [Youth] | - | Stade Rennais [Youth] | 4:3 | |
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| 14. Round | 05/12/2021 | Stade Rennais [Youth] | - | Girondins Bordeaux [Youth] | 0:0 | ||||
| 20. Round | 05/02/2022 | LB Châteauroux [Youth] | - | Stade Rennais [Youth] | 3:0 | ||||
| 21. Round | 12/02/2022 | Stade Rennais [Youth] | - | US Avranches [Youth] | 3:1 | |
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| 22. Round | 05/03/2022 | US Concarneau [Youth] | - | Stade Rennais [Youth] | 1:3 | |
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| 24. Round | 16/04/2022 | Le Mans FC [Youth] | - | Stade Rennais [Youth] | 0:5 |
France