| 2. Round | 20/08/2021 | Kayserispor | - | Adana Demirspor | 1:1 | ||||
| 4. Round | 11/09/2021 | Kayserispor | - | Kasımpaşa SK | 2:0 | ||||
| 5. Round | 19/09/2021 | Hatayspor | - | Kayserispor | 2:1 | ||||
| 6. Round | 22/09/2021 | Kayserispor | - | Galatasaray | 3:0 | ||||
| 7. Round | 26/09/2021 | Giresunspor | - | Kayserispor | 1:1 | ||||
| 9. Round | 18/10/2021 | Alanyaspor | - | Kayserispor | 6:3 |  |
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| 10. Round | 23/10/2021 | Konyaspor | - | Kayserispor | 2:0 | ||||
| 14. Round | 27/11/2021 | Çaykur Rizespor | - | Kayserispor | 1:0 | ||||
| 18. Round | 23/12/2021 | Yeni Malatyaspor | - | Kayserispor | 2:2 | ||||
| 20. Round | 09/01/2022 | Kayserispor | - | Altay Izmir | 1:0 | ||||
| 22. Round | 19/01/2022 | Kayserispor | - | İstanbul Başakşehir | 1:0 | ||||
| 23. Round | 23/01/2022 | Kasımpaşa SK | - | Kayserispor | 3:1 | ||||
| 36. Round | 06/05/2022 | Gaziantep FK | - | Kayserispor | 1:1 | |
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| 37. Round | 14/05/2022 | Kayserispor | - | Yeni Malatyaspor | 3:0 | ||||
| 38. Round | 21/05/2022 | Sivasspor | - | Kayserispor | 2:1 |
Turkey