| 1. Round | 18/07/2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 |  |
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| 2. Round | 24/07/2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 | ||||
| 3. Round | 28/07/2021 | Boca Juniors | - | San Lorenzo | 0:2 | |
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| 4. Round | 02/08/2021 | San Lorenzo | - | Banfield | 1:1 | |
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| 5. Round | 07/08/2021 | Unión de Santa Fe | - | San Lorenzo | 4:0 | ||||
| 10. Round | 04/09/2021 | Platense | - | San Lorenzo | 1:1 | ||||
| 11. Round | 13/09/2021 | San Lorenzo | - | Racing Club | 1:1 | |
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| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | |
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| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 16. Round | 18/10/2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 17. Round | 20/10/2021 | San Lorenzo | - | Lanús | 1:3 | |
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| 18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | |
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| 19. Round | 31/10/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 20. Round | 07/11/2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | |
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| 21. Round | 19/11/2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | ||||
| 22. Round | 23/11/2021 | Aldosivi | - | San Lorenzo | 2:0 | ||||
| 23. Round | 30/11/2021 | San Lorenzo | - | Sarmiento de Junín | 1:0 | ||||
| 24. Round | 05/12/2021 | Independiente | - | San Lorenzo | 1:1 | |
Colombia