| 6. Round | 10/09/2021 | Jong PSV | - | Jong Ajax | 3:1 | ||||
| 7. Round | 20/09/2021 | Jong PSV | - | ADO Den Haag | 0:1 | ||||
| 11. Round | 15/10/2021 | Roda JC Kerkrade | - | Jong PSV | 2:2 | ||||
| 10. Round | 18/10/2021 | Jong PSV | - | Telstar | 2:3 | ||||
| 12. Round | 22/10/2021 | Almere City FC | - | Jong PSV | 3:5 | ||||
| 13. Round | 01/11/2021 | Jong PSV | - | AZ Alkmaar (J) | 2:0 | ||||
| 14. Round | 05/11/2021 | Jong PSV | - | TOP Oss | 2:2 | ||||
| 16. Round | 19/11/2021 | FC Emmen | - | Jong PSV | 2:0 | ||||
| 15. Round | 22/11/2021 | Jong PSV | - | NAC Breda | 0:0 | ||||
| 18. Round | 06/12/2021 | Jong PSV | - | De Graafschap | 2:3 | ||||
| 19. Round | 10/12/2021 | FC Volendam | - | Jong PSV | 3:2 | ||||
| 23. Round | 21/01/2022 | Jong PSV | - | SBV Excelsior | 3:0 | ||||
| 28. Round | 25/02/2022 | NAC Breda | - | Jong PSV | 3:1 | ||||
| 29. Round | 07/03/2022 | Jong PSV | - | FC Emmen | 1:3 | ||||
| 33. Round | 01/04/2022 | AZ Alkmaar (J) | - | Jong PSV | 2:0 | ||||
| 37. Round | 29/04/2022 | De Graafschap | - | Jong PSV | 1:1 | ||||
| 38. Round | 06/05/2022 | Jong PSV | - | FC Dordrecht | 1:1 |
Belgium