| 21. Round | 15/01/2022 | Fatih Karagümrük | - | Çaykur Rizespor | 2:0 | ||||
| 23. Round | 23/01/2022 | Hatayspor | - | Çaykur Rizespor | 0:0 | ||||
| 24. Round | 06/02/2022 | Çaykur Rizespor | - | Adana Demirspor | 1:3 |  |
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| 25. Round | 11/02/2022 | Altay Izmir | - | Çaykur Rizespor | 0:0 | ||||
| 26. Round | 18/02/2022 | Çaykur Rizespor | - | İstanbul Başakşehir | 0:2 | ||||
| 27. Round | 27/02/2022 | Galatasaray | - | Çaykur Rizespor | 4:2 | ||||
| 28. Round | 05/03/2022 | Çaykur Rizespor | - | Giresunspor | 1:2 | ||||
| 29. Round | 12/03/2022 | Kasımpaşa SK | - | Çaykur Rizespor | 3:1 | ||||
| 30. Round | 18/03/2022 | Çaykur Rizespor | - | Trabzonspor | 3:2 | ||||
| 31. Round | 03/04/2022 | Alanyaspor | - | Çaykur Rizespor | 2:1 | ||||
| 34. Round | 22/04/2022 | Çaykur Rizespor | - | Fenerbahçe | 0:6 | ||||
| 35. Round | 01/05/2022 | Göztepe | - | Çaykur Rizespor | 1:7 | |
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| 36. Round | 08/05/2022 | Yeni Malatyaspor | - | Çaykur Rizespor | 1:3 | |
France