| Primera División | Matches | W | D | L |  |
 |
 |
| home | 8 | 4 | 1 | 3 | 7 | 1 | - |
| away | 10 | - | 5 | 5 | 29 | 1 | 1 |
| overall | 18 | 4 | 6 | 8 | 36 | 2 | 1 |
| Primera División | Home | - | Guest | |
|
|
Results |
| 23/08/15 | CF Monterrey | - | Santos Laguna | 5 | - | - | 1:1 |
| 27/09/15 | CF Pachuca | - | Santos Laguna | 2 | - | - | 0:0 |
| 01/11/15 | UANL Tigres | - | Santos Laguna | 5 | - | - | 2:2 |
| 07/02/16 | CF América | - | Santos Laguna | 3 | - | - | 2:0 |
| 07/05/16 | Santos Laguna | - | Deportivo Guadalajara | 1 | 1 | - | 0:1 |
| 18/03/17 | Club Tijuana | - | Santos Laguna | 3 | - | - | 1:1 |
| 24/04/17 | Santos Laguna | - | CF América | 1 | - | - | 2:1 |
| 23/07/17 | Lobos BUAP | - | Santos Laguna | 4 | - | - | 2:2 |
| 16/10/17 | Santos Laguna | - | Atlas Guadalajara | - | - | - | 0:1 |
| 31/03/18 | Atlas Guadalajara | - | Santos Laguna | 3 | 1 | - | 3:2 |
| 03/02/19 | UANL Tigres | - | Santos Laguna | 1 | - | 1 | 2:1 |
| 29/07/19 | Santos Laguna | - | FC Juárez | - | - | - | 3:0 |
| 08/03/20 | CF Pachuca | - | Santos Laguna | 3 | - | - | 1:0 |
| 08/03/21 | Santos Laguna | - | Club Necaxa | 1 | - | - | 3:1 |
| 03/05/21 | Santos Laguna | - | Puebla FC | 1 | - | - | 0:0 |
| 03/10/21 | Santos Laguna | - | Mazatlán FC | 2 | - | - | 1:0 |
| 01/04/24 | FC Juárez | - | Santos Laguna | - | - | - | 2:1 |
| 15/09/24 | Santos Laguna | - | CF Monterrey | 1 | - | - | 0:2 |
Mexico