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| 1st(1st leg) | Talleres de Córdoba | - | Atlético Tucumán | 3:2 (1:1) | ||
| 2nd (2nd leg) | Atlético Tucumán | - | Talleres de Córdoba | 2:0 (0:0) | ||
| 1st(1st leg): 27/04/2019 01:10 | 2nd (2nd leg): 04/05/2019 19:30 | Winner: Atlético Tucumán | ||||
| 1st(1st leg) | Lanús | - | Vélez Sarsfield | 1:2 (1:1) | ||
| 2nd (2nd leg) | Vélez Sarsfield | - | Lanús | 2:0 (2:0) | ||
| 1st(1st leg): 27/04/2019 21:45 | 2nd (2nd leg): 07/05/2019 01:10 | Winner: Vélez Sarsfield | ||||
| 1st(1st leg) | Estudiantes | - | Racing Club | 1:1 (0:1) | ||
| 2nd (2nd leg) | Racing Club | - | Estudiantes | 0:0 (0:0) | ||
| 1st(1st leg): 28/04/2019 00:00 | 2nd (2nd leg): 05/05/2019 00:00 | Winner: Racing Club | ||||
| 1st(1st leg) | Argentinos Juniors | - | San Lorenzo | 1:0 (1:0) | ||
| 2nd (2nd leg) | San Lorenzo | - | Argentinos Juniors | 1:1 (0:0) | ||
| 1st(1st leg): 28/04/2019 19:30 | 2nd (2nd leg): 05/05/2019 20:30 | Winner: Argentinos Juniors | ||||
| 1st(1st leg) | Aldosivi | - | River Plate | 1:1 (0:1) | ||
| 2nd (2nd leg) | River Plate | - | Aldosivi | 6:0 (2:0) | ||
| 1st(1st leg): 28/04/2019 21:45 | 2nd (2nd leg): 04/05/2019 01:10 | Winner: River Plate | ||||
| 1st(1st leg) | Godoy Cruz | - | Boca Juniors | 1:2 (0:1) | ||
| 2nd (2nd leg) | Boca Juniors | - | Godoy Cruz | 3:1 (1:0) | ||
| 1st(1st leg): 29/04/2019 00:00 | 2nd (2nd leg): 06/05/2019 00:00 | Winner: Boca Juniors | ||||
| 1st(1st leg) | Tigre | - | Unión de Santa Fe | 1:2 (0:2) | ||
| 2nd (2nd leg) | Unión de Santa Fe | - | Tigre | 1:3 (1:2) | ||
| 1st(1st leg): 29/04/2019 23:00 | 2nd (2nd leg): 04/05/2019 21:45 | Winner: Tigre | ||||
| 1st(1st leg) | Gimnasia de La Plata | - | Defensa y Justicia | 1:0 (1:0) | ||
| 2nd (2nd leg) | Defensa y Justicia | - | Gimnasia de La Plata | 0:2 (0:0) | ||
| 1st(1st leg): 30/04/2019 01:10 | 2nd (2nd leg): 05/05/2019 21:45 | Winner: Gimnasia de La Plata | ||||
