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| 1st(1st leg) | Universitario de Vinto | - | Universitario de Sucre | 2:1 | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Universitario de Vinto | 1:1 | ||
| 1st(1st leg): 04/12/2021 19:00 | 2nd (2nd leg): 11/12/2021 20:00 | Winner: Universitario de Vinto | ||||
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| 1st(1st leg) | Universitario de Vinto | - | Universitario de Sucre | 2:1 | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Universitario de Vinto | 1:1 | ||
| 1st(1st leg): 04/12/2021 19:00 | 2nd (2nd leg): 11/12/2021 20:00 | Winner: Universitario de Vinto | ||||
