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| 1st(1st leg) | Libertad Gran Mamoré | - | 24 de Septiembre de Santa Cruz | 5:3 | ||
| 2nd (2nd leg) | 24 de Septiembre de Santa Cruz | - | Libertad Gran Mamoré | 3:3 | ||
| 1st(1st leg): 18/11/2022 19:00 | 2nd (2nd leg): 22/11/2022 00:15 | Winner: Libertad Gran Mamoré | ||||
| 1st(1st leg) | Vaca Díez | - | Destroyers | 2:0 | ||
| 2nd (2nd leg) | Destroyers | - | Vaca Díez | 3:2 | ||
| 1st(1st leg): 18/11/2022 21:15 | 2nd (2nd leg): 21/11/2022 22:00 | Winner: Vaca Díez | ||||
