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| 1st(1st leg) | Escuela Enrique Happ | - | Libertad Gran Mamoré | 0:2 | ||
| 2nd (2nd leg) | Libertad Gran Mamoré | - | Escuela Enrique Happ | 2:0 | ||
| 1st(1st leg): 15/10/2022 18:00 | 2nd (2nd leg): 22/10/2022 20:00 | Winner: Libertad Gran Mamoré | ||||
| 1st(1st leg) | Deportivo JUVA | - | Destroyers | 1:1 | ||
| 2nd (2nd leg) | Destroyers | - | Deportivo JUVA | 1:0 | ||
| 1st(1st leg): 15/10/2022 20:00 | 2nd (2nd leg): 21/10/2022 18:00 | Winner: Destroyers | ||||
| 1st(1st leg) | Sur-Car | - | 24 de Septiembre de Santa Cruz | 2:1 | ||
| 2nd (2nd leg) | 24 de Septiembre de Santa Cruz | - | Sur-Car | 3:1 | ||
| 1st(1st leg): 16/10/2022 18:00 | 2nd (2nd leg): 21/10/2022 20:00 | Winner: 24 de Septiembre de Santa Cruz | ||||
| 1st(1st leg) | Vaca Díez | - | Deportivo FATIC | 1:1 | ||
| 2nd (2nd leg) | Deportivo FATIC | - | Vaca Díez | 6:7 pso | ||
| 1st(1st leg): 16/10/2022 20:00 | 2nd (2nd leg): 22/10/2022 18:00 | Winner: Vaca Díez | ||||
