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| 1st(1st leg) | Goiás - GO | - | Coritiba - PR | 1:0 (0:0) | ||
| 2nd (2nd leg) | Coritiba - PR | - | Goiás - GO | 1:1 (0:1) | ||
| 1st(1st leg): 28/02/2018 22:30 | 2nd (2nd leg): 14/03/2018 22:30 | Winner: Goiás - GO | ||||
| 1st(1st leg) | São Paulo FC | - | CR Brasil - AL | 2:0 (2:0) | ||
| 2nd (2nd leg) | CR Brasil - AL | - | São Paulo FC | 0:3 (0:1) | ||
| 1st(1st leg): 28/02/2018 22:30 | 2nd (2nd leg): 14/03/2018 22:30 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Náutico - PE | - | Cuiabá - MT | 2:1 (0:0) | ||
| 2nd (2nd leg) | Cuiabá - MT | - | Náutico - PE | 0:1 (0:0) | ||
| 1st(1st leg): 28/02/2018 22:30 | 2nd (2nd leg): 15/03/2018 00:45 | Winner: Náutico - PE | ||||
| 1st(1st leg) | Ponte Preta | - | Sampaio Corrêa - MA | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sampaio Corrêa - MA | - | Ponte Preta | 3:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 28/02/2018 22:30 | 2nd (2nd leg): 15/03/2018 22:15 | Winner: Ponte Preta | ||||
| 1st(1st leg) | CA Bragantino | - | Vitória - BA | 1:0 (1:0) | ||
| 2nd (2nd leg) | Vitória - BA | - | CA Bragantino | 3:0 (1:0) | ||
| 1st(1st leg): 28/02/2018 22:30 | 2nd (2nd leg): 15/03/2018 22:15 | Winner: Vitória - BA | ||||
| 1st(1st leg) | Ferroviário - CE | - | Vila Nova - GO | 1:1 (1:0) | ||
| 2nd (2nd leg) | Vila Nova - GO | - | Ferroviário - CE | 0:1 (0:1) | ||
| 1st(1st leg): 28/02/2018 23:30 | 2nd (2nd leg): 15/03/2018 23:30 | Winner: Ferroviário - CE | ||||
| 1st(1st leg) | Athletico Paranaense | - | Ceará - CE | 0:0 (0:0) | ||
| 2nd (2nd leg) | Ceará - CE | - | Athletico Paranaense | 5:6 (1:1, 1:1) pso | ||
| 1st(1st leg): 01/03/2018 00:30 | 2nd (2nd leg): 16/03/2018 00:30 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Figueirense - SC | - | Atlético Mineiro | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Figueirense - SC | 4:2 (1:1, 1:2) pso | ||
| 1st(1st leg): 01/03/2018 00:45 | 2nd (2nd leg): 15/03/2018 00:45 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Internacional | - | Cianorte - PR | 2:0 (0:0) | ||
| 2nd (2nd leg) | Cianorte - PR | - | Internacional | 0:2 (0:1) | ||
| 1st(1st leg): 01/03/2018 22:15 | 2nd (2nd leg): 14/03/2018 22:30 | Winner: Internacional | ||||
| 1st(1st leg) | Fluminense RJ | - | Avaí - SC | 1:2 (1:1) | ||
| 2nd (2nd leg) | Avaí - SC | - | Fluminense RJ | 1:0 (0:0) | ||
| 1st(1st leg): 01/03/2018 22:15 | 2nd (2nd leg): 16/03/2018 00:30 | Winner: Avaí - SC | ||||
